![]() Argyll Robertson pupils have four characteristic findings: (1) bilateral involvement, (2) small pupils that fail to dilate fully in dim light, (3) no light reaction, and (4) brisk constriction to near vision and brisk redilation to far vision. What is the mechanism of light-near dissociation due to Argyll Robertson pupils The distinction between the light-reflex and near-reflex pathways forms the basis for some forms of pupillary light-near dissociation (i.e., pupils that do not react to light but react to near stimuli) in which the dorsal midbrain and pretectal nuclei are damaged. Slit lamp examination often shows portions iris atrophy along with transillumination defects. Over time, AR pupils eventually lose their near constriction as well and become miotic and immobile. The pupils are not necessarily fixed to light, though they become. The cardinal features are summarised in table 3. The definition should be strict otherwise a whole host of pupillary abnormalities with some degree of light-near dissociation will be so designated. This process is experimental and the keywords may be updated as the learning algorithm improves. How is Argyll Robertson pupil diagnosed A. This light-near dissociation is bilateral in 80-90 of patients, but both pupillary size and degree of light-near dissociation can be asymmetric. ARGYLL ROBERTSON PUPIL Argyll Robertson described his pupillary syndrome in 1869. These keywords were added by machine and not by the authors. This specific diagnostic term is Argyll Robertson Pupil. A lesion of the dorsal midbrain can result in light-near dissociation by compressing and interrupting the more dorsally located fibers of the light reflex pathway and sparing the more. There is absent or diminished light reflex due to the reduced light impulses being carried to the pretectal nucleus however, these patients often retain the ability to determine object distance and have an intact near reflex. Severe loss of afferent light input to both eyes, such as a bilateral optic neuropathy, is a common cause of light-near dissociation. Light-near dissociation is a pathologic finding with several possible etiologies including severe loss of afferent light input to both eyes, a lesion of the dorsal midbrain, tonic pupils, aberrant reinnervation of the third nerve or ciliary ganglion fibers, and Argyll Robertson pupils.
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![]() For a 3 star the customer service was amazing. It is not a five star hotel but it doesn't say it is. ![]() We used Uber to get to Disney and found this worked really well. We bought cereal, toast and pop tarts and used breakfast as a snack at the park. Breakfast if you have read any reviews is what it is. We had a two bed suite and yes it is dated but it is lovely to have the space. Thank you to all the staff as this made a real difference to us. My son was mortified and they made no fuss which really helped. I rinsed it and took it to reception next day to ask for a fresh sheet. Due to the heat my son was sick and a little got thw top sheet. ![]() As it was during a storm they offered both sets of keys until morning so that we could move our things the next day. When they couldn't fix it they moved us rooms. We called down to reception and within 5mins maintenance were there. On our 2nd night we realised the ac wasn't working. Conveniences include safes and complimentary weekday newspapers, as well as phones with free local calls. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Complimentary wired and wireless Internet access keeps you connected, and cable programming provides entertainment. A roundtrip airport shuttle is complimentary (available 24 hours).Make yourself at home in one of the 180 air-conditioned rooms featuring refrigerators and flat-screen televisions. Planning an event in Orlando? This hotel has facilities measuring 1518 square feet (141 square meters), including conference space. Additional features at this hotel include complimentary wireless Internet access and tour/ticket assistance.A complimentary on-the-go breakfast is served daily from 7:00 AM to 9:00 AM.Featured amenities include a 24-hour business center, dry cleaning/laundry services, and a 24-hour front desk. This hotel is 10.5 mi (16.9 km) from Orlando International Premium Outlets and 11.1 mi (17.9 km) from Universal Orlando Resort.Take advantage of recreation opportunities including an outdoor pool and a 24-hour fitness center. Orlando | 2.85km from Nasa Store With a stay at Hampton Inn & Suites Orlando Airport Gateway Village in Orlando (Airport North), you'll be within a 15-minute drive of Florida Mall and Amway Center. ![]() We’ve found a product to suit every shade, skin type and preference. Keep reading to discover our favourite contouring palettes to get you going on your sculpting journey. Luckily for you, we have put our research to good use and compiled a list of every contour palette you need to know about. If you apply a lighter shade, for example, on the top of the cheekbone. Have you ever found yourself watching countless tutorials and scrolling contouring kits for hours? Yeah, same. FIGURE 6.4: DERMA COLOR PALETTE tools of highlight and contour to literally. If you wanna get to grips with the fundamentals of contouring, we have this handy tutorial with everything you need to know. COLORS, City Color Cosmetics, Lamora, youngfocus, W7, Vtrem. The possibilities are endless, with the right products of course. To assist you select the best contour palette for beginners brand, we examined all the features and came up with a list of ten possible purchases.You can see some famous brands as SHANY, Black Radiance, Aesthetica, L.A. This can include making the cheekbones look higher and more defined, chiselling the jaw, and defining the nose. Morphe palettes feature matte & shimmer finishes in a variety of sizes. Contouring is the method of sculpting and shaping your face to draw attention to certain features. Let your eyes do the talking with the best artistry and eyeshadow palettes for you. ![]() ![]() If you don’t already know, let’s take it back to basics. Back in the day contouring was reserved for the MUAs and the makeup pros, but thanks to a certain Kardashian and a whole load of makeup influencers, it quickly became a mainstream movement for everyday makeup. Buy diamond jewellery online at Kirtilals and glow in the ethereal beauty of diamonds. If you’re looking to buy online diamond jewellery, then Kirtilals is the right destination as it is the most trusted shop for diamonds and diamond jewellery. What’s more, the CarbonNeutral certification spans the full process of creating a beautiful Brilliance diamond, from product to its packaging, whilst the supply chain fully adheres to strict ethical, social, and environmental requirements, creating a range of diamonds that are as responsibly mined as they are dazzling.Įlsewhere in their collections, Pandora is working hard to reduce its environmental footprint, with a commitment to being carbon neutral across all its operations by 2025. In addition, the Danish jewellery brand has also committed to using 100% recycled silver and gold by the same period – making them the first major jewellery brand in the world to commit to this.Įxplore the Pandora Brilliance collection in your nearest store or online at Pandora.Nothing enhances your beauty like a well-crafted piece of jewellery, and the expert craftsmen at Kirtilals understand that. If you need another eco-friendly reason to treat a loved one (or yourself!) to an item, you’ll be pleased to hear that Pandora knows the origin of every diamond, and the process has achieved CarbonNeutral certification with each stone responsibly sourced in accordance with international human rights and labour standards. The solid 14k yellow gold studs are complimented by a sparkling 1 carat weight diamond to symbolise the infinite potential that lies in all of us. Pandora Brilliance 14k Gold 1.00 Carat TW Sparkling Teardrop Stud Earrings, £1,290, Pandora SHOP NOWĪs with all Pandora Brilliance earring pairs, these come with a certificate to warrant the size and quality of each stone. We’ve selected ten of our favourite pieces to give you some inspiration – whether you’re seeking the perfect present or indulging in some well-deserved self-gifting… Shop the Pandora Brilliance jewellery range Shine in your own unique way with Pandora Brilliance, and discover the beautiful bracelets, rings, necklaces and earrings, with each item featuring a round, brilliant cut diamond. Modelled by Ashley Graham and Rosario Dawson, items start at £250 with each unique stone ranging from 0.15 to 1 carat, democratising real diamonds for shoppers across the world. The Brilliance collection pioneers sustainably lab-created diamonds which are physically, chemically, and optically identical to their mined counterparts but created above ground. MORE: Here's how Pandora are giving back to the environment, one charm at a timeĬhiming with the event and building on its progress towards a more eco-friendly and ethical future, Pandora is the jewellery brand leading the way. The day aims to unite individuals and organisations across the globe to create a more sustainable environment for generations to come. Pioneered in the 1970s, Earth Day has been commemorated for the past 52 years and the theme for 2022 is ‘Invest In Our Planet’. Making more environmentally-friendly choices with our wardrobes will always be in style – and with Earth Day approaching on 22 April, it's never been more timely to consider the impact our shopping habits have on the planet. ![]() He is anything and anyone you require him to be, and you get the sense that he’s just happy to be in a position to oblige such directorial desires.Īny chance, then, that we get to talk about Richard Jenkins is a good thing. Jenkins excels at playing the man you would underestimate most, until it’s too late. A simple spinal adjustment later, he’s the stern patriarch ( Six Feet Under). Slightly hunched, he exudes a profound air of quiet desperation ( Olive Kitteridge). With his unassuming frame and inscrutable face, the 73-year-old can easily play the sleaze ( Killing Them Softly, The Cabin in the Woods), the confidant ( Eat Pray Love), the doofus ( Burn After Reading) or the blowhard ( Step Brothers). The long-time character actor, who got a boost in 2009 thanks to his Oscar nomination for The Visitor and another in 2018 for The Shape of Water, is easily one of the most prolific performers of his generation, and for good reason. Which is both good and bad news for fans of Richard Jenkins, who happens to star in both. So while I sincerely hope that Kajillionaire and The Last Shift, this weekend’s fresh sacrifices to the gods of theatrical exhibition, will somehow reverse course and make millions, I’m skeptical. I’ve always wanted these kinds of original films to receive as marquee a multiplex placement as the latest Avengers or Jurassic Park adventure. ![]() Which is exactly what’s happening to low-stakes and generally excellent fare such as The Nest, The Personal History of David Copperfield and The Broken Hearts Gallery – all “now playing,” though good luck if you can find someone who has taken cinemas up on the offer. ![]() Here is a table summarizing the price for each McDonald’s coffee item depending on the size: McDonald’s coffee found on the $1 $2 $3 Dollar Menu include: Luckily, you can find coffee on the $1 McDonald’s Coffee menu, although the $1 McDonald’s menu now includes $1, $2, and $3 menu items. McDonald’s Iced Coffee calories range between 90- 670. The McDonald’s Iced Coffees have 4- 17g of fat, 7- 60g of carbohydrates, and 2- 7g of protein. The only common allergen found in McDonald’s Iced Coffees is milk, but it is present in all of them. The Iced Latte is the lowest calorie coffee on the McDonald’s Iced Coffee menu (90 calories). The Iced Latte has 4.5g of fat, 7g of carbs, and 4g of protein. The Iced Latte is made up of espresso, water, whole milk, and ice. The only allergen in the Iced Coffee is the milk. The Caramel and Mocha Frappes have the most calories (420 calories). The Caramel Frappe is made with a caramel coffee frappe base, ice, whipped cream, and caramel sauce. The Mocha Frappe is made with a mocha coffee frappe base, ice, whipped cream, and chocolate sauce.īoth Caramel and Mocha Frappes have 17g of fat, 60g of carbs, and 7g of protein, and the only allergen found in both is milk. You can find three standard iced coffees on the McDonald’s Coffee menu that are all relatively low in calories. The plain Iced Coffee and Iced Caramel Coffee are 140 calories. The Iced French Vanilla Coffee is just a bit lower and has 120 calories. The base of each standard iced coffee is premium-roast coffee, ice, light cream, and liquid sugar. The Iced Caramel Coffee has added caramel syrup, and the Iced French Vanilla has French vanilla syrup added. The Iced French Vanilla has 5g of fat, 19g of carbs, and 2g of protein. The Iced Caramel Coffee has 5g of fat, 23g of carbs, and 3g of protein. Lastly, plain Iced Coffee has 5g of fat, 24g of carbs, and 2g of protein. In addition to their plain Iced Latte, McDonald’s offers two flavored Iced Lattes on their coffee menu. The Iced Caramel Latte contains 180 calories, 5g of fat, 28g of carbs, and 6g of protein. The Iced Caramel Latte is made with espresso, water, ice, whole milk, and caramel syrup. The Iced French Vanilla Latte contains 160 calories, 6g of fat, 32g of carbs, and 7g of protein. The Iced French Vanilla Latte is made with espresso, water, ice, whole milk, and French vanilla syrup. ![]() The McDonald’s Coffee menu also contains two unique iced coffees – Iced Caramel Macchiato and Iced Mocha. Both are on the higher end of calories compared to the rest of the McDonald’s Iced Coffee menu. The Iced Caramel Macchiato is made with espresso, water, ice, whole milk, caramel syrup, and caramel drizzle. It has 210 calories, 6g of fat, 32g of carbs, and 6g of protein. The Iced Mocha is made with espresso, water, ice, whole milk, chocolate syrup, whipped cream, and chocolate drizzle. Here is a table detailing the calories in each size of McDonald’s Iced Coffee: It has 280 calories, 10g of fat, 39g of carbs, and 7g of protein. 2) I wanted to see how the mechanical and visual changes impacted vibration. I left the motors in for two reasons: 1) Tactile feedback is a key component of the DualSense and many modern games, so unless you’re only planning on using the controller for competitive Call of Duty: Black Ops Cold War, removing the motors means you’re missing out. Upon request, Aim will remove the motors that generate vibration in the body of the controller. Lastly, there’s one gameplay-relevant change I passed on. The grip feels good and holds your fingers in place, but seems like a better fit for controllers without rear paddles, where your hands will make complete contact with the gamepad’s rear face. I went for the smallest possible sticks (only 2mm higher than Sony’s) and didn’t notice a meaningful difference. I also added a rubberized paint-splatter grip to the rear of the controller. ![]() By default, Aim swaps out the analog sticks for their taller, third-party version. There are a couple of other small gameplay-relevant changes. If you ever become annoying or you're not using them, all you have to do is twist the central Aim Controller logo on the back, and then you can remove the paddles as you would on many other third-party controllers. The good news is the back paddles are removeable. (Or plan to keep an extra unmodded DualSense handy). I wouldn’t add them unless you're dead-set on using them day in and day out. Along with the permanently shortened trigger pulls, you can't unlock the low-profile buttons. If there’s one major issue across most of these extras, it’s that they’re all or nothing. Luckily, the restriction is limited to that one, specific feature: The triggers still rumble when they’re supposed to. In competitive shooters, this is a boon – though I believe most games let you turn it off – but the fact that you lose access to the haptic feedback, which is a big part of what makes the DualSense special, is disappointing. Specifically, the controller no longer generates resistance that forces you to pull the triggers harder. Shortening the travel negates some of the haptic feedback functionality of the controller. There are some serious downsides to the smart buttons, though – especially the smart triggers. It impacts comfort more than performance, but it’s a persistent annoyance. ![]() The L1 button sometimes sticks momentarily after a hard tap. I found the smart bumpers to be somewhat finicky. They do the job well: The button press is short, and it does lead to quicker actuation. If you’ve used trigger locks on a third-party controller, the smart buttons are essentially permanently locked for minimum travel and maximum efficiency. The two other primary add-ons are low-profile “smart” triggers and bumpers, which shorten the top buttons to a very short press (1mm travel). Though it never caused a problem, I generally prefer visual UI for customization tools – it helps me figure out what works best. Changing buttons is easy, but there’s no indicator letting you know when a change has been made or what the change is. If you buy the remappable version, you can change the inputs to match any of the buttons except the triggers (L2 and R2) using an onboard programming tool. I haven’t pushed them to the brink, but they seem prone to snap under duress, like if you slam the controller onto a messy desk or shove it into a bag full of pencils and other things that could wedge between the paddle and controller’s body. Their one downside is durability: Made from a cheaper plastic than the faceplate and other components, the paddles will bend if you push or pull them the wrong way. ![]() The paddles have a quick press and deliver light tactile feedback: They aren’t as pleasing to press as face buttons, but with a little practice you can generally hit them faster and more precisely. This puts them in the perfect positions under your fingers, which is great when you want to use them, but not so great if you want to ignore them, because you will press them by mistake from time to time. ![]() The hard plastic paddles reach out from a base in the center of the controller’s back faceplate, curving around the handles to reach your middle- and ring-fingers’ natural resting points. First, it features remappable rear paddles. The controller I built, which would cost $274 to reproduce (including the cost of the DualSense), features all of Aim’s mechanical add-ons. Check the effect below:Ī dark mode is basically a design option in the UI design of the devices and tools. You can now open any PDF document with UPDF on your iPhone and iPad and enjoy the night mode. This is how you convert PDF to dark mode on iOS. ![]() Once on the "Display and Brightness" interface, select the "Dark" option to turn on the dark mode. Instructions: To turn on dark mode on iPhone or iPad, launch "Settings" and go to the "Display and Brightness" option. Don't fret because enabling dark mode on UPDF for iPhone or iPad is not challenging as you think. If you have just switched from iOS, you may not know how to enable the dark mode on UPDF to have a PDF night mode experience. The dark mode of UPDF for iOS can also help to boost your productivity. Students tend to read PDF files on iPhones and iPad because these are not heavy devices. IPhone and iPad are known to provide the best-in-class functionality to help users in their daily tasks. Part 2: How Can I Read PDF in Dark Mode on iPhone and iPad Take the blue color as an example, the effect will be like as follows, and of course, you can set any color you like. Learn detailed instructions on how to change the PDF background color. You can also customize its opacity and apply it by tapping the "Save" button. Instructions: to make the whole PDF file dark mode, select the "Page Tools" icon from the left panel and click on "Background." To continue, choose the "Add" button and select the black color from the available options. UPDF offers you another way to change the background of your PDF document to a dark color, which will provide you with a better experience with your eyes. Please note that this will only change the color of the interface, and will not change the color of the PDF file itself.ġ00% secure How to Turn Your Whole PDF File in Dark BackgroundĪfter enabling the dark mode, if you still think the document itself is too bright. You can now enjoy reading PDFs in this night mode. Now you will find that your UPDF's interface becomes in dark mode. By this, your Mac will be modified to dark mode, and you can use UPDF in dark mode. From the right panel, enable the "Dark " appearance feature. Instructions: To enable dark mode on Mac, click "Apple Logo" and select "System Settings." Following this, locate the "Appearance" option and launch it. ![]() How to Enable the Dark Mode Interface of UPDF on Mac It lets you organize, edit, merge, and split PDF files effortlessly. You can also use this tool to convert PDF into other file formats. This dark mode PDF reader will reduce the screen's brightness and let you work in a comfortable environment. To resolve this matter, you can use the built-in dark mode feature of UPDF for Mac. This can weaken your eyesight and can also cause headaches. You need to handle and read several PDF files daily and need to use devices for a long time. ![]() Mac encompasses several valuable features to boost the productivity of users. Want to write your own ebook? Check out the best free software for writers.100% secure Part 1: How Do I Read PDF in Dark Mode on Mac?.Read our full Icecream Ebook Reader review.Students will find the lack of note-taking and copying frustrating. The free version of Icecream Ebook Reader is quick and very easy to use, but only really suitable for recreational reading. Premium features include importing multiple ebooks simultaneously, adding notes, editing metadata, and copying text. Unfortunately, some of the options you can see in the menus are only available if you pay for the Pro version. The reader itself is similar to the Kindle app in appearance, with one-click (or tap) buttons for changing font size, color theme (day, night, or sepia), and viewing the table of contents. One particularly handy feature is the ability to archive and export your ebooks ideal if you use more than one PC and don’t want the hassle of importing your books twice. It supports EPUB, MOBI, PDF and FB2 ebook formats, and once you’ve imported your books they’re arranged in a neat bookshelf with a choice of viewing options. Icecream specializes in smart, no-frills software, and Icecream Ebook Reader is no exception. ![]() This suggests that people exposed to radiation from the Chernobyl accident didn’t pass on any adverse effects to their children. The number of DNMs found in the children was similar to that in the general population. Such “de novo” mutations (DNMs) will appear in children’s genomes but not in either parent’s. ![]() The team looked for random, spontaneous mutations that occurred in the parents’ sperm and eggs. ![]() The scientists estimated each parent’s radiation exposure based on parents’ reports of their activity and knowledge of environmental radiation around the power plant. The children were all born at least 46 weeks after the accident and up to the year 2002. The parents had either worked on cleaning up after the accident or were evacuated from the nearby town. The researchers sequenced the genomes of 130 children and their parents. Stephen Chanock and Meredith Yeager, examined whether radiation exposure causes genetic damage that can be passed to offspring. Results were published on April 22, 2021, in Science. The studies were led by researchers at NIH’s National Cancer Institute (NCI). Two studies examining the genetic changes in those in the area at the time of the accident and their children provide new insights into the health effects of radiation exposure. Such radiation is known to cause changes, or mutations, in DNA. In April 1986, an accidental reactor explosion at the Chernobyl nuclear power plant in present-day Ukraine exposed millions of people in the surrounding area to radioactive contaminants. I'm not a scientist, of course, so I can't give an educated answer as to whether it's too late, but I passionately hope it isn't.Researchers used DNA sequencing technology to explore the effects of radiation from the Chernobyl nuclear disaster. Nor has the threat of a nuclear disaster lessened, from either weapons or accidents. My optimism has been dampened lately by the stream of reports about arctic ice melting and governments unwilling to take the necessary steps to slow down climate change. Some of the photographs have an emotional resonance because of the health consequences the accident had for so many people, and this has been most acute for me with the photographs of kindergartens and playgrounds.ĭo you consider yourself an optimist in regard to environmental issues? An example is slippers and toys on a kindergarten floor that has extraordinary color. There are some photographs I love for their unexpected beauty. Photographing the reactor from a fixed vantage point over the years, as well as Soviet flags in a stairwell, are examples that are intellectually satisfying. With so many photographs made over a long period, there are several that seem key, in the sense they opened me to looking at a situation as having a rich photographic potential. Is there a specific image or story behind an image that means a great deal to you ? I have to say that on every visit, there were situations which I hadn't previously realized could make an interesting photograph, but suddenly seemed to have possibilities. The zone was changing, and I wanted that to be part of the body of work. The rephotographing of sites I had seen on previous visits became important, and photographs of floors and vegetation became new subjects for me. As I gained a sense of the scope of what was possible, I realized there were several themes I responded to, such as the abundance of Soviet-era artifacts and the aforementioned growth and decay. My original visit in 1994 was speculative in the sense that I didn't know what I'd find or how freely I'd be allowed to travel. When looking back at years of work, were there new narratives or interesting details that you might have overlooked or not been aware of at the time? As the threat of radiation has diminished, the proliferation of wild boars has been somewhat concerning, but the current hazard is the buildings that are collapsing. As far as safety is concerned, I accepted that there was a risk of sorts, but I was advised where the most highly contaminated areas were and to spend less time there. ![]() In addition to mining the rest of The Witching Hour for material, Mayfair Witches Season 2 (and potential future installments) could lean into the following two books, Lasher and Taltos, to further explore the Mayfairs’ mythology. Esta Spalding and Michelle Ashford create the show. So we used a piece of that, and then we feel like we’re gonna save some of that great story and saga of all the different generations for later seasons - should we be so lucky.” Mayfair Witches Season 2 is an American supernatural thriller drama television series. The middle section is about 300 or 400 pages of 13 generations of witches going all the way back to Scotland. ![]() “It’s very, very long and full of lots of amazing stuff. “The book is kind of an embarrassment of riches,” she said, per Rotten Tomatoes. Mayfair Witches Season 2 PlotĪs showrunner Esta Spalding explained at a Television Critics Association panel last year, the first season of Mayfair Witches generally corresponded to the first book in Rice’s trilogy - but there’s more to explore in Season 2 and beyond. Hubbard speaks to Matthew about Tom’s death. As he walks away, we cut back to 1590’s London. ![]() Domenico walks through a crime scene as he uncovers a dead body sporting multiple bite marks across the neck. Yes, that even includes the final season of The Walking Dead.Īfter getting to know Rowan and her witch heritage in Season 1, what’s next? Here’s everything to know about Mayfair Witches Season 2 so far. Episode 3 of A Discovery of Witches Season 2 starts in Oxford, England in the present. 3, after becoming “most-viewed season of any series ever on AMC+,” the network writes. Mayfair Witches Season 2 was officially announced on Feb. AMC’s Interview with the Vampireand Mayfair Witchesare part of the network’s new Immortal Universe based on Anne Rice’s novels - and like the best TV empires (looking at you, Yellowstone), this one is only going to get bigger. |
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